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Cell-Free Degradation of p27(kip1), a G(1) Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome
Entry into S phase is dependent on the coordinated activation of CDK4,6 and CDK2 kinases. Once a cell commits to S phase, there must be a mechanism to ensure the irreversibility of this decision. The activity of these kinases is inhibited by their association with p27. In many cells, p27 plays a maj...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
1999
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC116048/ https://ncbi.nlm.nih.gov/pubmed/9891053 |
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