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Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

The retinoblastoma protein (pRb) acts to constrain the G(1)-S transition in mammalian cells. Phosphorylation of pRb in G(1) inactivates its growth-inhibitory function, allowing for cell cycle progression. Although several cyclins and associated cyclin-dependent kinases (cdks) have been implicated in...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Lundberg, Ante S., Weinberg, Robert A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 1998
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC108786/
https://ncbi.nlm.nih.gov/pubmed/9447971
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