Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents

We assessed the pharmacokinetics and safety of solithromycin, a fluoroketolide antibiotic, in a phase 1, open-label, multicenter study of 13 adolescents with suspected or confirmed bacterial infections. On days 3 to 5, the mean (standard deviation) maximum plasma concentration and area under the con...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Gonzalez, Daniel, Palazzi, Debra L., Bhattacharya-Mithal, Leena, Al-Uzri, Amira, James, Laura P., Bradley, John, Neu, Natalie, Jasion, Theresa, Hornik, Christoph P., Smith, P. Brian, Benjamin, Daniel K., Keedy, Kara, Fernandes, Prabhavathi, Cohen-Wolkowiez, Michael
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808196/
https://ncbi.nlm.nih.gov/pubmed/26883693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02561-15
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