Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents

Solithromycin is a novel fluoroketolide antibiotic which was under investigation for the treatment of community-acquired bacterial pneumonia (CABP). A phase 1 study was performed to characterize the pharmacokinetics (PK) and safety of solithromycin in children. Eighty-four subjects (median age, 6 ye...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Gonzalez, Daniel, James, Laura P., Al-Uzri, Amira, Bosheva, Miroslava, Adler-Shohet, Felice C., Mendley, Susan R., Bradley, John S., Espinosa, Claudia, Tsonkova, Eva, Moffett, Kathryn, Marquez, Lucila, Simonsen, Kari A., Stoilov, Stefan, Boakye-Agyeman, Felix, Jasion, Theresa, Hornik, Christoph P., Hernandez, Robert, Benjamin, Daniel K., Cohen-Wolkowiez, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2018
Предметы:
Clinical Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105834/
https://ncbi.nlm.nih.gov/pubmed/29891609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00692-18
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