Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae

Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mut...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Arena, Fabio, Henrici De Angelis, Lucia, Cannatelli, Antonio, Di Pilato, Vincenzo, Amorese, Marina, D'Andrea, Marco Maria, Giani, Tommaso, Rossolini, Gian Maria
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808163/
https://ncbi.nlm.nih.gov/pubmed/26824959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02981-15
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