In Vivo Evolution to Colistin Resistance by PmrB Sensor Kinase Mutation in KPC-Producing Klebsiella pneumoniae Is Associated with Low-Dosage Colistin Treatment

Colistin is a key drug for the treatment of infections caused by extensively drug-resistant strains of Enterobacteriaceae producing carbapenemases. However, the emergence of colistin resistance is being increasingly reported, especially among Klebsiella pneumoniae strains producing KPC-type carbapen...

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Autors principals: Cannatelli, Antonio, Di Pilato, Vincenzo, Giani, Tommaso, Arena, Fabio, Ambretti, Simone, Gaibani, Paolo, D'Andrea, Marco Maria, Rossolini, Gian Maria
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136067/
https://ncbi.nlm.nih.gov/pubmed/24841267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02555-14
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