In Vivo Emergence of Colistin Resistance in Klebsiella pneumoniae Producing KPC-Type Carbapenemases Mediated by Insertional Inactivation of the PhoQ/PhoP mgrB Regulator

Colistin is one of the few agents that retain activity against extensively drug-resistant strains of Klebsiella pneumoniae producing KPC-type carbapenemases (KPC-KP). However, resistance to colistin is increasingly reported among KPC-KP. Comparative genomic analysis of a pair of sequential KPC-KP is...

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Detalhes bibliográficos
Main Authors: Cannatelli, Antonio, D'Andrea, Marco Maria, Giani, Tommaso, Di Pilato, Vincenzo, Arena, Fabio, Ambretti, Simone, Gaibani, Paolo, Rossolini, Gian Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811314/
https://ncbi.nlm.nih.gov/pubmed/23979739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01480-13
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