Synthesis of Mitomycin C and Decarbamoylmitomycin C N(2) deoxyguanosine-adducts

Mitomycin C (MC) and Decarbamoylmitomycin C (DMC) -a derivative of MC lacking the carbamate on C10- are DNA alkylating agents. Their cytotoxicity is attributed to their ability to generate DNA monoadducts as well as intrastrand and interstrand cross-links (ICLs). The major monoadducts generated by M...

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Veröffentlicht in:Bioorg Chem
Hauptverfasser: Champeil, Elise, Cheng, Shu-Yuan, Huang, Bik Tzu, Conchero-Guisan, Marta, Martinez, Thibaut, Paz, Manuel, Sapse, Anne-Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807628/
https://ncbi.nlm.nih.gov/pubmed/26894558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2016.02.003
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