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Synthesis of Mitomycin C and Decarbamoylmitomycin C N(2) deoxyguanosine-adducts
Mitomycin C (MC) and Decarbamoylmitomycin C (DMC) -a derivative of MC lacking the carbamate on C10- are DNA alkylating agents. Their cytotoxicity is attributed to their ability to generate DNA monoadducts as well as intrastrand and interstrand cross-links (ICLs). The major monoadducts generated by M...
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| Publicado en: | Bioorg Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4807628/ https://ncbi.nlm.nih.gov/pubmed/26894558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2016.02.003 |
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