CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries

BACKGROUND: Genetic screens using CRISPR/Cas9 are a powerful method for the functional analysis of genomes. RESULTS: Here we describe CRISPR library designer (CLD), an integrated bioinformatics application for the design of custom single guide RNA (sgRNA) libraries for all organisms with annotated g...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Biol
Prif Awduron: Heigwer, Florian, Zhan, Tianzuo, Breinig, Marco, Winter, Jan, Brügemann, Dirk, Leible, Svenja, Boutros, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Software
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807595/
https://ncbi.nlm.nih.gov/pubmed/27013184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0915-2
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