GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia

GATA-1 and PU.1 are two important hematopoietic transcription factors that mutually inhibit each other in progenitor cells to guide entrance into the erythroid or myeloid lineage, respectively. PU.1 controls its own expression during myelopoiesis by binding to the distal URE enhancer, whose deletion...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Burda, Pavel, Vargova, Jarmila, Curik, Nikola, Salek, Cyril, Papadopoulos, Giorgio Lucio, Strouboulis, John, Stopka, Tomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807078/
https://ncbi.nlm.nih.gov/pubmed/27010793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152234
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