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PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure
Transcriptional repression mechanisms are important during differentiation of multipotential hematopoietic progenitors, where they are thought to regulate lineage commitment and to extinguish alternative differentiation programs. PU.1 and GATA-1 are two critical hematopoietic transcription factors t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276718/ https://ncbi.nlm.nih.gov/pubmed/16222338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600834 |
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