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PU.1 Activation Relieves GATA-1–Mediated Repression of Cebpa and Cbfb during Leukemia Differentiation

Hematopoietic transcription factors GATA-1 and PU.1 bind each other on DNA to block transcriptional programs of undesired lineage during hematopoietic commitment. Murine erythroleukemia (MEL) cells that coexpress GATA-1 and PU.1 are blocked at the blast stage but respond to molecular removal (downre...

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Detalhes bibliográficos
Main Authors: Burda, Pavel, Curik, Nikola, Kokavec, Juraj, Basova, Petra, Mikulenkova, Dana, Skoultchi, Arthur I., Zavadil, Jiri, Stopka, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193075/
https://ncbi.nlm.nih.gov/pubmed/19825991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0031
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