Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation

The oncogenic cluster miR-17-92 encodes seven related microRNAs that regulate cell proliferation, apoptosis and development. Expression of miR-17-92 cluster is decreased upon cell differentiation. Here, we report a novel mechanism of the regulation of miR-17-92 cluster. Using transgenic PU.1(−/−) my...

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Detalhes bibliográficos
Main Authors: Pospisil, Vit, Vargova, Karin, Kokavec, Juraj, Rybarova, Jana, Savvulidi, Filipp, Jonasova, Anna, Necas, Emanuel, Zavadil, Jiri, Laslo, Peter, Stopka, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230374/
https://ncbi.nlm.nih.gov/pubmed/21897363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.317
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