Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(−/−) Mice

Genetic ablation of cellular prion protein (PrP(C)) has been linked to increased neuronal excitability and synaptic activity in the hippocampus. We have previously shown that synaptic activity in hippocampi of PrP-null mice is increased due to enhanced N-methyl-D-aspartate receptor (NMDAR) function....

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Fan, Jing, Stemkowski, Patrick L., Gandini, Maria A., Black, Stefanie A., Zhang, Zizhen, Souza, Ivana A., Chen, Lina, Zamponi, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805597/
https://ncbi.nlm.nih.gov/pubmed/27047338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00074
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