Gastrointestinal safety, chemotherapeutic potential, and classic pharmacological profile of NOSH‐naproxen (AVT‐219) a dual NO‐ and H(2)S‐releasing hybrid

Naproxen (NAP) is a potent nonsteroidal anti‐inflammatory drug (NSAID) with a favorable cardiovascular profile. However, its long‐term use may lead to serious gastrointestinal and renal side effects. NOSH‐ (nitric oxide and hydrogen sulfide) releasing naproxen (NOSH‐NAP, AVT‐219) belongs to a new cl...

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Bibliographic Details
Published in:Pharmacol Res Perspect
Main Authors: Chattopadhyay, Mitali, Kodela, Ravinder, Duvalsaint, Pascale L., Kashfi, Khosrow
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804313/
https://ncbi.nlm.nih.gov/pubmed/27069635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.224
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