Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling()

We recently reported the synthesis of NOSH-aspirin, a novel hybrid that releases both nitric oxide (NO) and hydrogen sulfide (H(2)S). In NOSH-aspirin, the two moieties that release NO and H(2)S are covalently linked at the 1, 2 positions of acetyl salicylic acid, i.e. ortho-NOSH-aspirin (o-NOSH-aspi...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Vannini, Federica, Chattopadhyay, Mitali, Kodela, Ravinder, Rao, Praveen P.N., Kashfi, Khosrow
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556775/
https://ncbi.nlm.nih.gov/pubmed/26319435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.08.014
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