Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. PARK2 mutations cause early-onset forms of PD. PARK2 encodes an E3 ubiquitin ligase, Parkin, that can selectively translocate to dysfunctional mitochondria to promote thei...

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Bibliografski detalji
Izdano u:Neuron
Glavni autori: Pickrell, Alicia M., Huang, Chiu-Hui, Kennedy, Scott R., Ordureau, Alban, Sideris, Dionisia P., Hoekstra, Jake G., Harper, J. Wade, Youle, Richard J.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803114/
https://ncbi.nlm.nih.gov/pubmed/26182419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.06.034
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