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Inhibition of the tyrosine phosphatase STEP(61) restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice
Brain-derived neurotrophic factor (BDNF) and STriatal-Enriched protein tyrosine Phosphatase 61 (STEP(61)) have opposing functions in the brain, with BDNF supporting and STEP(61) opposing synaptic strengthening. BDNF and STEP(61) also exhibit an inverse pattern of expression in a number of brain diso...
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| Veröffentlicht in: | Cell Mol Life Sci |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer International Publishing
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4801664/ https://ncbi.nlm.nih.gov/pubmed/26450419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2057-1 |
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