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STriatal-Enriched protein tyrosine Phosphatase (STEP) Regulates the PTPα/Fyn Signaling Pathway

The tyrosine kinase Fyn has two regulatory tyrosine residues that when phosphorylated either activate (Tyr(420)) or inhibit (Tyr(531)) Fyn activity. Within the central nervous system, two protein tyrosine phosphatases (PTPs) target these regulatory tyrosines in Fyn. PTPα dephosphorylates Tyr(531) an...

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Pubblicato in:J Neurochem
Autori principali: Xu, Jian, Kurup, Pradeep, Foscue, Ethan, Lombroso, Paul J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516628/
https://ncbi.nlm.nih.gov/pubmed/25951993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13160
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