Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP(61)

Amyloid β (Aβ) is involved in the etiology of Alzheimer's disease (AD) and may contribute to cognitive deficits by increasing internalization of ionotropic glutamate receptors. Striatal-enriched protein tyrosine phosphatase 61 (STEP(61)), which is targeted in part to the postsynaptic terminal,...

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Main Authors: Kurup, Pradeep, Zhang, Yongfang, Xu, Jian, Venkitaramani, Deepa V., Haroutunian, Vahram, Greengard, Paul, Nairn, Angus C., Lombroso, Paul J.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868326/
https://ncbi.nlm.nih.gov/pubmed/20427654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0157-10.2010
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