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Inhibition of the tyrosine phosphatase STEP(61) restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice
Brain-derived neurotrophic factor (BDNF) and STriatal-Enriched protein tyrosine Phosphatase 61 (STEP(61)) have opposing functions in the brain, with BDNF supporting and STEP(61) opposing synaptic strengthening. BDNF and STEP(61) also exhibit an inverse pattern of expression in a number of brain diso...
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| 發表在: | Cell Mol Life Sci |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer International Publishing
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4801664/ https://ncbi.nlm.nih.gov/pubmed/26450419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2057-1 |
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