Inhibition of the tyrosine phosphatase STEP(61) restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice

Brain-derived neurotrophic factor (BDNF) and STriatal-Enriched protein tyrosine Phosphatase 61 (STEP(61)) have opposing functions in the brain, with BDNF supporting and STEP(61) opposing synaptic strengthening. BDNF and STEP(61) also exhibit an inverse pattern of expression in a number of brain diso...

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書目詳細資料
發表在:Cell Mol Life Sci
Main Authors: Xu, Jian, Kurup, Pradeep, Baguley, Tyler D., Foscue, Ethan, Ellman, Jonathan A., Nairn, Angus C., Lombroso, Paul J.
格式: Artigo
語言:Inglês
出版: Springer International Publishing 2015
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801664/
https://ncbi.nlm.nih.gov/pubmed/26450419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2057-1
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