Inhibition of the tyrosine phosphatase STEP(61) restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice

Brain-derived neurotrophic factor (BDNF) and STriatal-Enriched protein tyrosine Phosphatase 61 (STEP(61)) have opposing functions in the brain, with BDNF supporting and STEP(61) opposing synaptic strengthening. BDNF and STEP(61) also exhibit an inverse pattern of expression in a number of brain diso...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Xu, Jian, Kurup, Pradeep, Baguley, Tyler D., Foscue, Ethan, Ellman, Jonathan A., Nairn, Angus C., Lombroso, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801664/
https://ncbi.nlm.nih.gov/pubmed/26450419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2057-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados