Inhibition of the tyrosine phosphatase STEP(61) restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice

Brain-derived neurotrophic factor (BDNF) and STriatal-Enriched protein tyrosine Phosphatase 61 (STEP(61)) have opposing functions in the brain, with BDNF supporting and STEP(61) opposing synaptic strengthening. BDNF and STEP(61) also exhibit an inverse pattern of expression in a number of brain diso...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Mol Life Sci
Main Authors: Xu, Jian, Kurup, Pradeep, Baguley, Tyler D., Foscue, Ethan, Ellman, Jonathan A., Nairn, Angus C., Lombroso, Paul J.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801664/
https://ncbi.nlm.nih.gov/pubmed/26450419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2057-1
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki