Reduced Levels of the Tyrosine Phosphatase STEP Block Beta Amyloid-mediated GluA1/GluA2 Receptor Internalization

STEP(61) is a protein tyrosine phosphatase recently implicated in the pathophysiology of Alzheimer’s disease (AD). STEP(61) is elevated in human AD prefrontal cortex and in the cortex of several AD mouse models. The elevated levels of active STEP(61) down-regulate surface expression of GluN1/GluN2B...

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Main Authors: Zhang, Yongfang, Kurup, Pradeep, Xu, Jian, Anderson, George M., Greengard, Paul, Nairn, Angus C., Lombroso, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192910/
https://ncbi.nlm.nih.gov/pubmed/21883219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07450.x
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