Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disorder. Early in the pathophysiology of AD, synaptic function is disrupted by soluble Aβ oligomers, possibly through Aβ-mediated internalization of NMDA receptors. Striatal-enriched phosphatase (STEP) is a tyrosine phos...

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Bibliografiske detaljer
Main Authors: Zhang, Yongfang, Kurup, Pradeep, Xu, Jian, Carty, Nikisha, Fernandez, Stephanie M., Nygaard, Haakon B., Pittenger, Christopher, Greengard, Paul, Strittmatter, Stephen M., Nairn, Angus C., Lombroso, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973892/
https://ncbi.nlm.nih.gov/pubmed/20956308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013543107
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