Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer

Microsatellite instability (MSI-H) is caused by DNA mismatch repair deficiency and occurs in 15% of colorectal cancers. MSI-H cancers generate highly immunogenic frameshift peptide (FSP) antigens, which elicit pronounced local immune responses. A subset of MSI-H colorectal cancers develops in frame...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Echterdiek, Fabian, Janikovits, Jonas, Staffa, Laura, Müller, Meike, Lahrmann, Bernd, Frühschütz, Monika, Hartog, Benjamin, Nelius, Nina, Benner, Axel, Tariverdian, Mirjam, von Knebel Doeberitz, Magnus, Grabe, Niels, Kloor, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801455/
https://ncbi.nlm.nih.gov/pubmed/27057447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1075692
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