High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer

DNA mismatch repair (MMR)-deficient cancers accumulate high numbers of coding microsatellite mutations, which lead to the generation of highly immunogenic frameshift peptide (FSP) neoantigens. MMR-deficient cells can grow out to clinically manifest cancers either if they evade immune cell attack or...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Janikovits, Jonas, Müller, Meike, Krzykalla, Julia, Körner, Sandrina, Echterdiek, Fabian, Lahrmann, Bernd, Grabe, Niels, Schneider, Martin, Benner, Axel, Doeberitz, Magnus von Knebel, Kloor, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749658/
https://ncbi.nlm.nih.gov/pubmed/29308317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1390640
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