Vaccine-induced but not tumor-derived Interleukin-10 dictates the efficacy of Interleukin-10 blockade in therapeutic vaccination

Blocking antibodies against immunosuppressive molecules have shown promising results in cancer patients. However, there are not enough data to define those conditions dictating treatment efficacy. In this scenario, IL-10 is a cytokine with controversial effects on tumor growth. Thus, our aim was to...

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Publicado en:Oncoimmunology
Autores principales: Llopiz, Diana, Aranda, Fernando, Díaz-Valdés, Nancy, Ruiz, Marta, Infante, Stefany, Belsúe, Virginia, Lasarte, Juan José, Sarobe, Pablo
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801433/
https://ncbi.nlm.nih.gov/pubmed/27057445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1075113
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