Inhibition of adjuvant-induced TAM receptors potentiates cancer vaccine immunogenicity and therapeutic efficacy

Analyzing immunomodulatory elements operating during antitumor vaccination in prostate cancer patients and murine models we identified IL-10-producing DC as a subset with poorer immunogenicity and clinical efficacy. Inhibitory TAM receptors MER and AXL were upregulated on murine IL-10(+) DC. Thus, w...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Llopiz, Diana, Ruiz, Marta, Silva, Leyre, Reparaz, David, Aparicio, Belén, Egea, Josune, Lasarte, Juan J., Redin, Esther, Calvo, Alfonso, Angel, Matthew, Berzofsky, Jay A., Stroncek, David, Sarobe, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006848/
https://ncbi.nlm.nih.gov/pubmed/33232788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.11.022
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