Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence

Viral proteins are not naturally selected for high affinity major histocompatibility complex (MHC) binding sequences; indeed, if there is any selection, it is likely to be negative in nature. Thus, one should be able to increase viral peptide binding to MHC in the rational design of synthetic peptid...

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Bibliographic Details
Main Authors: Ahlers, Jeffrey D., Takeshita, Toshiyuki, Pendleton, C. David, Berzofsky, Jay A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23507/
https://ncbi.nlm.nih.gov/pubmed/9380724
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