Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence

Viral proteins are not naturally selected for high affinity major histocompatibility complex (MHC) binding sequences; indeed, if there is any selection, it is likely to be negative in nature. Thus, one should be able to increase viral peptide binding to MHC in the rational design of synthetic peptid...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ahlers, Jeffrey D., Takeshita, Toshiyuki, Pendleton, C. David, Berzofsky, Jay A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10856
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