Inhibition of adjuvant-induced TAM receptors potentiates cancer vaccine immunogenicity and therapeutic efficacy

Analyzing immunomodulatory elements operating during antitumor vaccination in prostate cancer patients and murine models we identified IL-10-producing DC as a subset with poorer immunogenicity and clinical efficacy. Inhibitory TAM receptors MER and AXL were upregulated on murine IL-10(+) DC. Thus, w...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Lett
Auteurs principaux: Llopiz, Diana, Ruiz, Marta, Silva, Leyre, Reparaz, David, Aparicio, Belén, Egea, Josune, Lasarte, Juan J., Redin, Esther, Calvo, Alfonso, Angel, Matthew, Berzofsky, Jay A., Stroncek, David, Sarobe, Pablo
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006848/
https://ncbi.nlm.nih.gov/pubmed/33232788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.11.022
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires