Vaccine-induced but not tumor-derived Interleukin-10 dictates the efficacy of Interleukin-10 blockade in therapeutic vaccination

Blocking antibodies against immunosuppressive molecules have shown promising results in cancer patients. However, there are not enough data to define those conditions dictating treatment efficacy. In this scenario, IL-10 is a cytokine with controversial effects on tumor growth. Thus, our aim was to...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Llopiz, Diana, Aranda, Fernando, Díaz-Valdés, Nancy, Ruiz, Marta, Infante, Stefany, Belsúe, Virginia, Lasarte, Juan José, Sarobe, Pablo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801433/
https://ncbi.nlm.nih.gov/pubmed/27057445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1075113
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