Helper cell-independent antitumor activity of potent CD8(+) T cell epitope peptide vaccines is dependent upon CD40L

Peptide vaccines derived from CD8(+) T-cell epitopes have shown variable efficacy in cancer patients. Thus, some peptide vaccines are capable of activating CD8(+) T-cell responses, even in the absence of CD4(+) T-cell epitopes or dendritic cell (DC)-activating adjuvants. However, the mechanisms unde...

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Bibliographic Details
Main Authors: Llopiz, Diana, Huarte, Eduardo, Ruiz, Marta, Bezunartea, Jaione, Belsúe, Virginia, Zabaleta, Aintzane, Lasarte, Juan J, Prieto, Jesús, Borrás-Cuesta, Francisco, Sarobe, Pablo
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897504/
https://ncbi.nlm.nih.gov/pubmed/24498563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.27009
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