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T-bet promotes potent antitumor activity of CD4(+) CAR T cells

Chimeric antigen receptor (CAR) therapy has shown promise against B cell malignancies in the clinic. However, limited success in patients with solid tumors has prompted the development of new CAR strategies. In this study, a B7H6-specific CAR was combined with different variants of T-bet, a transcri...

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Detalhes bibliográficos
Publicado no:Cancer Gene Ther
Main Authors: Gacerez, Albert T, Sentman, Charles L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021366/
https://ncbi.nlm.nih.gov/pubmed/29515240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41417-018-0012-7
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