In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia

Several recent clinical trials have successfully incorporated a costimulatory domain derived from either CD28 or 4-1BB with the original CD3ζ T cell activating domain to form second-generation chimeric antigen receptors (CARs) that can increase the responsiveness and survival of CAR-engineered T (CA...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Cheng, Zhi, Wei, Runhong, Ma, Qiuling, Shi, Lin, He, Feng, Shi, Zixiao, Jin, Tao, Xie, Ronglin, Wei, Baofeng, Chen, Jing, Fang, Hongliang, Han, Xiaolu, Rohrs, Jennifer A., Bryson, Paul, Liu, Yarong, Li, Qi-Jing, Zhu, Bo, Wang, Pin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079368/
https://ncbi.nlm.nih.gov/pubmed/29503204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.01.022
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