T cells engrafted with a UniCAR 28/z outperform UniCAR BB/z-transduced T cells in the face of regulatory T cell-mediated immunosuppression

Adoptive transfer of chimeric antigen receptor (CAR)-equipped T cells have demonstrated astonishing clinical efficacy in hematological malignancies recently culminating in the approval of two CAR T cell products. Despite this tremendous success, CAR T cell approaches have still achieved only moderat...

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Detalhes bibliográficos
Main Authors: Alexandra Kegler, Stefanie Koristka, Ralf Bergmann, Nicole Berndt, Claudia Arndt, Anja Feldmann, Anja Hoffmann, Martin Bornhäuser, Marc Schmitz, Michael P. Bachmann
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2019-09-01
Colecção:OncoImmunology
Assuntos:
chimeric antigen receptor
intracellular signaling domain
regulatory t cells
immunosuppression
tumor immunotherapy
solid tumor
Acesso em linha:http://dx.doi.org/10.1080/2162402X.2019.1621676
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