Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3

Amyloid β-protein (Aβ) pathologies have been linked to dysfunction of excitability in neurons of the hippocampal circuit, but the molecular mechanisms underlying this process are still poorly understood. Here, we applied whole-cell patch-clamp electrophysiology to primary hippocampal neurons and sho...

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Bibliografiska uppgifter
I publikationen:Neurobiol Aging
Huvudupphovsmän: Scala, Federico, Fusco, Salvatore, Ripoli, Cristian, Piacentini, Roberto, Li Puma, Domenica Donatella, Spinelli, Matteo, Laezza, Fernanda, Grassi, Claudio, D’Ascenzo, Marcello
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801354/
https://ncbi.nlm.nih.gov/pubmed/25541422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.10.034
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