Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly understood. Here, we demonstrate that HFD increases palmitic acid deposition in the hippocampus and induces hippocampal insulin resi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Spinelli, Matteo, Fusco, Salvatore, Mainardi, Marco, Scala, Federico, Natale, Francesca, Lapenta, Rosita, Mattera, Andrea, Rinaudo, Marco, Li Puma, Domenica Donatella, Ripoli, Cristian, Grassi, Alfonso, D’Ascenzo, Marcello, Grassi, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722929/
https://ncbi.nlm.nih.gov/pubmed/29222408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02221-9
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