Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly understood. Here, we demonstrate that HFD increases palmitic acid deposition in the hippocampus and induces hippocampal insulin resi...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Spinelli, Matteo, Fusco, Salvatore, Mainardi, Marco, Scala, Federico, Natale, Francesca, Lapenta, Rosita, Mattera, Andrea, Rinaudo, Marco, Li Puma, Domenica Donatella, Ripoli, Cristian, Grassi, Alfonso, D’Ascenzo, Marcello, Grassi, Claudio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722929/
https://ncbi.nlm.nih.gov/pubmed/29222408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02221-9
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars