Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3

Amyloid β-protein (Aβ) pathologies have been linked to dysfunction of excitability in neurons of the hippocampal circuit, but the molecular mechanisms underlying this process are still poorly understood. Here, we applied whole-cell patch-clamp electrophysiology to primary hippocampal neurons and sho...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Scala, Federico, Fusco, Salvatore, Ripoli, Cristian, Piacentini, Roberto, Li Puma, Domenica Donatella, Spinelli, Matteo, Laezza, Fernanda, Grassi, Claudio, D’Ascenzo, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801354/
https://ncbi.nlm.nih.gov/pubmed/25541422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.10.034
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