Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels

Although major depressive disorder (MDD) is highly prevalent, its pathophysiology is poorly understood. Recent evidence suggests that glycogen-synthase kinase 3β (GSK3β) plays a key role in memory formation, yet its role in mood regulation remains controversial. Here, we investigated whether GSK3β a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Aceto, Giuseppe, Colussi, Claudia, Leone, Lucia, Fusco, Salvatore, Rinaudo, Marco, Scala, Federico, Green, Thomas A., Laezza, Fernanda, D’Ascenzo, Marcello, Grassi, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149226/
https://ncbi.nlm.nih.gov/pubmed/32209671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917423117
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