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Structural basis for DNA cleavage by the potent antiproliferative agent (–)-lomaiviticin A
(–)-Lomaiviticin A (1) is a complex antiproliferative metabolite that inhibits the growth of many cultured cancer cell lines at low nanomolar–picomolar concentrations. (–)-Lomaiviticin A (1) possesses a C(2)-symmetric structure that contains two unusual diazotetrahydrobenzo[b]fluorene (diazofluorene...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4801295/ https://ncbi.nlm.nih.gov/pubmed/26929332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519846113 |
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