Cell Non-Autonomous Activation of Flavin-containing Monooxygenase Promotes Longevity and Healthspan

Stabilization of the hypoxia-inducible factor-1 (HIF-1) increases lifespan and healthspan in nematodes through an unknown mechanism. We report that neuronal stabilization of HIF-1 mediates these effects in C. elegans through a cell non-autonomous signal to the intestine resulting in activation of th...

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Udgivet i:Science
Main Authors: Leiser, Scott F., Miller, Hillary, Rossner, Ryan, Fletcher, Marissa, Leonard, Alison, Primitivo, Melissa, Rintala, Nicholas, Ramos, Fresnida J., Miller, Dana L., Kaeberlein, Matt
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801033/
https://ncbi.nlm.nih.gov/pubmed/26586189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac9257
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