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Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities

Immunological adjuvants such as the saponin natural product QS-21 help stimulate the immune response to co-administered antigens and have become increasingly important in the development of prophylactic and therapeutic vaccines. However, clinical use of QS-21 is encumbered by chemical instability, d...

詳細記述

保存先:
書誌詳細
出版年:Chem Sci
主要な著者: Walkowicz, William E., Fernández-Tejada, Alberto, George, Constantine, Corzana, Francisco, Jiménez-Barbero, Jesús, Ragupathi, Govind, Tan, Derek S., Gin, David Y.
フォーマット: Artigo
言語:Inglês
出版事項: Royal Society of Chemistry 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800320/
https://ncbi.nlm.nih.gov/pubmed/27014435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc02978c
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