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Antagonism of the STING pathway via activation of the AIM2 inflammasome by intracellular DNA

Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic cells via the host STING pathway is a major mechanism leading to spontaneous T cell responses against tumors. However, the impact of the other major pathway triggered by intracellular DNA, the AIM2 inflammasome, o...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Corrales, Leticia, Woo, Seng-Ryong, Williams, Jason, McWhirter, Sarah M., Dubensky, Thomas W., Gajewski, Thomas F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800192/
https://ncbi.nlm.nih.gov/pubmed/26927800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502538
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