Notch Signaling in Postnatal Joint Chondrocytes, but not Subchondral Osteoblasts, is Required for Articular Cartilage and Joint Maintenance

OBJECTIVE: Notch signaling has been identified as a critical regulator in cartilage development and joint maintenance, and loss of Notch signaling in all joint tissues results in an early and progressive osteoarthritis (OA)-like pathology. This study investigated the targeted cell population within...

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Veröffentlicht in:Osteoarthritis Cartilage
Hauptverfasser: Liu, Zhaoyang, Ren, Yinshi, Mirando, Anthony J., Wang, Cuicui, Zuscik, Michael J., O’Keefe, Regis J., Hilton, Matthew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799757/
https://ncbi.nlm.nih.gov/pubmed/26522700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2015.10.015
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