TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages

TAK1 is a MAP3K that mediates non-canonical TGF-β and BMP signaling. During the embryonic period, TAK1 is essential for cartilage and joint development as deletion of Tak1 in chondro-osteo progenitor cells leads to severe chondrodysplasia with defects in both chondrocyte proliferation and maturation...

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Detalhes bibliográficos
Main Authors: Gao, Lin, Sheu, Tzong-jen, Dong, Yufeng, Hoak, Donna M., Zuscik, Michael J., Schwarz, Edward M., Hilton, Matthew J., O’Keefe, Regis J., Jonason, Jennifer H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860312/
https://ncbi.nlm.nih.gov/pubmed/24144697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.135483
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