Aberrant hypertrophy in Smad3-deficient chondrocytes is rescued by restoring TAK1-ATF-2 signaling: a potential clinical implication for osteoarthritis

OBJECTIVE: To investigate the biological significance of Smad3 in the progression of osteoarthritis (OA), the crosstalk between Smad3 and ATF-2 in the TGF-β signaling pathway, and the effects of ATF-2 overexpression and p38 activation in chondrocyte differentiation. METHODS: Joint disease in Smad3 k...

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Main Authors: Li, Tian-Fang, Gao, Lin, Sheu, Tzong-Jen, Sampson, Erik R., Flick, Lisa M., Konttinen, Yrjo T., Chen, Di, Schwarz, Edward M., Zuscik, Michael J., Jonason, Jennifer H., O’Keefe, Regis J.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921996/
https://ncbi.nlm.nih.gov/pubmed/20506210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27537
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