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BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway
OBJECTIVE: BMP-2 is approved for fracture non-union and spine fusion. We aimed to further dissect its downstream signaling events in chondrocytes with the ultimate goal to develop novel therapeutics that can mimic BMP-2 effect but have less complications. METHODS: BMP-2 effect on COX-2 expression wa...
שמור ב:
Main Authors: | , , , , , , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
2014
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947583/ https://ncbi.nlm.nih.gov/pubmed/24418675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2013.12.020 |
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