BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway

OBJECTIVE: BMP-2 is approved for fracture non-union and spine fusion. We aimed to further dissect its downstream signaling events in chondrocytes with the ultimate goal to develop novel therapeutics that can mimic BMP-2 effect but have less complications. METHODS: BMP-2 effect on COX-2 expression wa...

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Detalhes bibliográficos
Main Authors: Li, Tian-Fang, Yukata, Kiminori, Yin, Guoyong, Sheu, Tzongjen, Maruyama, Takamitsu, Jonason, Jennifer H., Hsu, Wei, Zhang, Xinping, Xiao, Guozhi, Konttinen, Yrjo T., Chen, Di, O’Keefe, Regis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947583/
https://ncbi.nlm.nih.gov/pubmed/24418675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2013.12.020
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