A Dual Role for NOTCH Signaling in Joint Cartilage Maintenance and Osteoarthritis

Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis (OA), indicating a requirement for NOTCH during joint cartilage maintenance. Unexpectedly, NOTCH components are significantly up-regulated in human and murine post-traumatic OA, suggesting either a reparative or pathologica...

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Udgivet i:Sci Signal
Main Authors: Liu, Zhaoyang, Chen, Jianquan, Mirando, Anthony, Wang, Cuicui, Zuscik, Michael J., O’Keefe, Regis J., Hilton, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607068/
https://ncbi.nlm.nih.gov/pubmed/26198357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa3792
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