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A Dual Role for NOTCH Signaling in Joint Cartilage Maintenance and Osteoarthritis
Loss of NOTCH signaling in postnatal murine joints results in osteoarthritis (OA), indicating a requirement for NOTCH during joint cartilage maintenance. Unexpectedly, NOTCH components are significantly up-regulated in human and murine post-traumatic OA, suggesting either a reparative or pathologica...
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| Vydáno v: | Sci Signal |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4607068/ https://ncbi.nlm.nih.gov/pubmed/26198357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa3792 |
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